- Thyroid
- Thyroid Dysfunction Associated with Administration of the Long-Acting Gonadotropin-Releasing Hormone Agonist
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Eun Jin Han, Ha Do Song, Ji Hoon Yang, So Young Park, Sung Hoon Kim, Hyun Koo Yoon, Chang Hoon Yim
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Endocrinol Metab. 2013;28(3):221-225. Published online September 13, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.3.221
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Abstract
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Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.
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Citations
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- Thyroid Dysfunction after Gonadotropin-Releasing Hormone Agonist Administration in Women with Thyroid Autoimmunity
Loris Marin, Guido Ambrosini, Marco Noventa, Flavia Filippi, Eugenio Ragazzi, Francesco Dessole, Giampiero Capobianco, Alessandra Andrisani, Alexander Schreiber International Journal of Endocrinology.2022; 2022: 1. CrossRef - Effects of controlled ovarian stimulation on thyroid function during pregnancy
Lingfei Li, Ling Li, Ping Li Biology of Reproduction.2022; 107(6): 1376. CrossRef - Is gonadotropin-releasing hormone agonist usage really leading to thyroid dysfunction?
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Naoki Gocho, Ema Aoki, Chiho Okada, Takeshi Hirashima Internal Medicine.2018; 57(21): 3117. CrossRef - The impact of thyroid autoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis
Andrea Busnelli, Alessio Paffoni, Luigi Fedele, Edgardo Somigliana Human Reproduction Update.2016; 22(6): 775. CrossRef - The Potential Role of GnRH Agonists and Antagonists in Inducing Thyroid Physiopathological Changes During IVF
Salvatore Gizzo, Marco Noventa, Michela Quaranta, Amerigo Vitagliano, Federica Esposito, Alessandra Andrisani, Roberta Venturella, Carlo Alviggi, Mario Plebani, Michele Gangemi, Giovanni Battista Nardelli, Donato D’Antona Reproductive Sciences.2016; 23(4): 515. CrossRef - Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
- A Case of Hypothyroidism in Remission during Pregnancy.
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Ha Do Song, Eun Jin Han, Sung Ja Lee, Ji Hoon Yang, So Young Park, Sung Hoon Kim, Ki Ok Han, Hyun Koo Yoon, Chang Hoon Yim
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Endocrinol Metab. 2012;27(4):295-298. Published online December 20, 2012
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DOI: https://doi.org/10.3803/EnM.2012.27.4.295
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Abstract
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- Hypothyroidism should be treated in pregnancy, because it has been associated with an increased risk of adverse pregnancy complications, as well as detrimental effects upon fetal neurocognitive development. The goal of L-thyroxine (LT4) treatment is to normalize maternal serum TSH values within the trimester-specific pregnancy reference range. 50% to 85% of hypothyroid women being treated with exogenous LT4 need to increase the dose during pregnancy. In this study, we report a case of a 29-year-old woman with hypothyroidism who had been in remission and discontinued LT4 treatment during her pregnancy. Three months after delivery she had a relapse of hypothyroidism and was retreated with LT4. Many factors can influence the gestational requirement for LT4, therefore maternal serum TSH should be monitored and the LT4 dose should be adjusted in pregnant patients with treated hypothyroidism.
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